Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! Thousands of dogs have experienced serious adverse reactions after taking . Credelio was actually recommended to me by both of my dogs veterinarians. Oh no! Best of luck with your new girl! Frontline Plus targets four kinds of ticks, fleas (including eggs and larvae), lice, and mites that cause sarcoptic mange. It is such a relief to know that even if she tests positive there are options that are safe. Selamectin is their shared main ingredient. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. We do eat it! Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Hi there , thank you for putting this information up! Unless youre, say, an expat living in China, you can definitely find a better option. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! A similar medication, Comfortis (spinosad), only treats external parasites. The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. 5 types of ticks (the only proven chewable for most type of ticks elimination) The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Do you know what the ingredients are in the medicated shampoo? I plan to switch him over to Trifexis also. If your Collie doesnt play like that, you should be fine. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. 1x 20mg tablet for 11.1 to 22 pounds. No treatment-related clinical signs were observed. My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. Took that collar right off her. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. My question is about Capstar. Thank you! I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Thank you for bringing this to my attention! The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. , Thanks for the reply! After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. Thank you for your very informative article. The flavored, chewable tablets were consumed . Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. It probably is the safest as it is aimed only at preventing heartworm. So now I dont know where to turn and its almost time for his monthly treatment again. That averages out to about 212 deaths per year. This is so thorough and helpful! I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Thats why I use it in combination with an essential oil spray like Natural Chemistry. Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. Will you be updating this article with regard to Seresto? Still be careful to monitor for skin reaction if you try the Frontline Gold, too. Simparica TRIO for X-Large Dogs - 88 - 132 lbs - BROWN - 6 tablets (In Stock) $116.95: . We often go on walks in the woods. My plan is to adopt a senior Border to go with my lazy Roughs. In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. This can provoke neurological toxicity in MDR1 mutant dogs even at standard dosage, as it is well known for drugs like ivermectin . Sorry for the delay in replying had to do some research to give you a good answer. Hi Debbie! ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. In FL resistance is bad, and we split our time between FL & NJ. I gave a mini aussie and a minnie aussie/border collie mix. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. The oral chew contains a specially optimised trio of ingredients for . I will try to find the article again, I stupidly didnt bookmark it. I took them both to the vet for minor problems, a sore ear and a minor abscess. Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. Thanks. However, it did make my Collies too itchy. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. In a laboratory study, the product was . I hate to use anything, but also tired of keeping my dogs in a bubble. $153.89. One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. I hope you get this. The best thing about Seresto is how long it can do its job up to 8 months! I would appreciate your comments on Advocate. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. Simparica Trio is proven to kill 5 species of ticks. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. Simparica Trio works against the same ticks as Nexgard and also protects your dog from heartworms, hookworms, and roundworms. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. Your article was appreciated and helpful! $161.99. Thank you again for all your help : ). The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. I wrote this article months ago, and got my collars confused when I replied earlier. What do you know about this? This is a new extensively tested product now available in Australia that provides optimal protection for your dog. Another safe heartworm medication is the daily dimmitrol. Dogs, 6 Month Supply. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. Giardia can be passed to and cause diarrhea in humans. Last year I used Frontline Plus with no issues. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. 1,9 And the fact is, dogs love both chews. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. However, as with any chemical compounds, caution is advised even with products deemed to be safe. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. Please let me know how the Wondercide works for you! Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. If you think about it, come back here and let me and other readers know what worked best for you! Best of luck! From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. We have a almost 10 year old tricolor rough collie, named Hollie. Doses used for heartworm prevention are safe to use in these breeds of dogs. The flea pills and chews all contain a pesticide called isoxazoline, the FDA said . Enjoy your girl! (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. The accidental ingestion of the product may potentially result in . Thank you so much for writing this article!!! Evoluciona. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. . Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. I honestly didnt know they existed until I started researching more to answer your question. Thanks for reply. For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. Simparica. With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . The topical medicines seem to work best with her, but dont do much to keep the tics at bay. Giardia can be passed to and cause diarrhea in humans. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. thanks for your research. 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